New approach uses 'cloaked' proteins to deliver cancer-killing therapeutics into cells

Image
Schematic of the bioreversible anionic cloaking strategy. Chemical modification of surface-exposed lysines with sulfonated cloaking reagents enables complexation and subsequent delivery of protein cargos with cationic lipids. Following endocytic escape, the reagents are cleaved off via the presence of a self-immolative, redox-sensitive disulfide bond to tracelessly deliver the cargo protein in the cytoplasm of a cell. Credit: ACS Central Science (2024). DOI: 10.1021/acscentsci.4c00071 An interdisciplinary collaboration has designed a way to «cloak» proteins so that they can be captured by lipid nanoparticles, which are akin to tiny bubbles of fat. These bubbles are small enough to sneak their hidden cargo into living cells, where the proteins uncloak and exert their therapeutic effect. The generalizable technique could lead to repurposing thousands of commercial protein products, including antibodies, for biological research an...
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Le Mans 2024 livestream: Watch 24 Hours of Le Mans for free

TL;DR: Live stream 24 Hours of Le Mans for free on ServusTV or L’Equipe TV. Access these free streaming platforms from anywhere in the world with ExpressVPN.

Gather round fans of motor racing, because one of the biggest events of the year is set to take place in France. So sit back, relax, and prepare yourself for probably the most famous endurance race in the world.

If you’re interested in watching 24 Hours of Le Mans for free from anywhere in the world, we have all the information you need.

What is 24 Hours of Le Mans?

Le Mans is an endurance race held annually near the town of Le Mans, France. It’s the world’s oldest active endurance racing event, and unlike fixed-distance races, Le Mans is won by the car that covers the greatest distance in 24 hours.

When is 24 Hours of Le Mans in 2024?

The 2024 24 Hours of Le Mans is the 92nd Grand Prix of Endurance. This year’s event is scheduled to take place on June 15-16 at the Circuit de la Sarthe in Le Mans, France.

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How to watch 24 Hours of Le Mans for free

The good news is that you can stream all the action from 24 Hours of Le Mans for free on these platforms:

ServusTV and L’Equipe TV are geo-restricted to Austria and France respectively, which means you’ll need to use a VPN to stream on these free platforms. VPNs can hide your real IP address (digital location) and connect you to a secure server in Austria or France. This process makes it look like you’re connecting from Austria or France, so you can access ServusTV or L’Equipe TV from anywhere in the world.

Unblock ServusTV and L’Equipe TV by following these simple steps:

  1. Sign up for a streaming-friendly service (like ExpressVPN)

  2. Download the app to your device of choice (the best VPNs have apps for Windows, Mac, iOS, Android, Linux, and more)

  3. Open up the app and connect to a server in Austria or France

  4. Connect to ServusTV or L’Equipe TV

  5. Watch 24 Hours of Le Mans for free from anywhere in the world

The best VPNs for streaming are not free, but leading services do tend to offer pretty generous money-back guarantees. By using these offers, you can unblock ServusTV and L’Equipe TV without fully committing with your cash. This clearly isn’t a long-term solution to free streaming, but it does give you the opportunity to stream 24 Hours of Le Mans before recovering your investment.

What is the best VPN for streaming?

ExpressVPN is the best service for unblocking streaming sites from around the world, for a number of reasons:

  • Servers in 105 countries including Austria and France

  • Easy-to-use app available on all major devices including iPhone, Android, Windows, Mac, and more

  • Strict no-logging policy

  • Fast streaming speeds free from throttling

  • Up to eight simultaneous connections

  • 30-day money-back guarantee

A one-year subscription to ExpressVPN is on sale for $99.95 and includes an extra three months for free — 49% off for a limited time. This plan also includes a year of free unlimited cloud backup and a 30-day money-back guarantee. You can sign up to watch Le Mans and then recover your investment without hassle after the race.

Watch 24 Hours of Le Mans for free with ExpressVPN.

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