New approach uses 'cloaked' proteins to deliver cancer-killing therapeutics into cells

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Schematic of the bioreversible anionic cloaking strategy. Chemical modification of surface-exposed lysines with sulfonated cloaking reagents enables complexation and subsequent delivery of protein cargos with cationic lipids. Following endocytic escape, the reagents are cleaved off via the presence of a self-immolative, redox-sensitive disulfide bond to tracelessly deliver the cargo protein in the cytoplasm of a cell. Credit: ACS Central Science (2024). DOI: 10.1021/acscentsci.4c00071 An interdisciplinary collaboration has designed a way to «cloak» proteins so that they can be captured by lipid nanoparticles, which are akin to tiny bubbles of fat. These bubbles are small enough to sneak their hidden cargo into living cells, where the proteins uncloak and exert their therapeutic effect. The generalizable technique could lead to repurposing thousands of commercial protein products, including antibodies, for biological research an...
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Get Microsoft Office and Windows 11 Pro for life for 79% off

TL;DR: Score the Microsoft Office lifetime license and Windows 11 Pro bundle on sale for $85.97 (reg. $418.99) through June 17.

Despite the flood of alternatives, Microsoft’s apps continue to hold their ground. Microsoft Office is still the go-to productivity suite in offices everywhere. And Windows remains the reigning champion of operating systems for computers and laptops. The catch? They’re not exactly budget-friendly. But there’s a great deal that gives you access for life today.

Through June 17, you can score a lifetime license to Microsoft Office and Windows 11 Pro for life for just $85.97 (reg. $418.99).

This all-in-one bundle is the ultimate upgrade for your computer. Windows 11 Pro and Microsoft Office Pro 2021 are designed to work together seamlessly, bringing you the latest in productivity and security. In case you didn’t know, Microsoft Office 2021 needs Windows 11 to run, and this bundle neatly packages them together.

With this deal, you get full access to the Pro 2021 versions of Word, Excel, PowerPoint, Outlook, Teams, OneNote, Publisher, and Access. Unlike Microsoft 365, which requires you to fork over cash every month, this is a one-time payment, offering better long-term value and saving you from succumbing to an endless subscription.

As for Windows 11 Pro, this upgrade equips your computer with top-notch security, management, and productivity features. We’re talking about an improved user interface, enhanced search functions, Windows Information Protection to keep personal and work data separate, Microsoft Information Protection integration to safeguard your info from leaks, and BitLocker Encryption to make your hard drive unreadable without the right key.

Mashable Deals

Upgrade your computer in one fell swoop with the Microsoft Office and Windows 11 Pro bundle. Through June 17, you can get it on sale for only $85.97 — no coupon necessary.

StackSocial prices subject to change.

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New approach uses 'cloaked' proteins to deliver cancer-killing therapeutics into cells

Image
Schematic of the bioreversible anionic cloaking strategy. Chemical modification of surface-exposed lysines with sulfonated cloaking reagents enables complexation and subsequent delivery of protein cargos with cationic lipids. Following endocytic escape, the reagents are cleaved off via the presence of a self-immolative, redox-sensitive disulfide bond to tracelessly deliver the cargo protein in the cytoplasm of a cell. Credit: ACS Central Science (2024). DOI: 10.1021/acscentsci.4c00071 An interdisciplinary collaboration has designed a way to «cloak» proteins so that they can be captured by lipid nanoparticles, which are akin to tiny bubbles of fat. These bubbles are small enough to sneak their hidden cargo into living cells, where the proteins uncloak and exert their therapeutic effect. The generalizable technique could lead to repurposing thousands of commercial protein products, including antibodies, for biological research an...
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The upper-left schematic illustrates the flow of a zinc-air battery (ZAB). The iron-cobalt-nickel (Fe-Co-Ni) electrocatalyst (upper right) speeds both the charging and discharging of the ZAB compared to binary metal electrocatalysts or noble metals platinum and ruthenium, which occurs through the oxygen evolution reaction and oxygen reduction reaction, respectively. The diagram in the lower left illustrates the assembly of the ZAB with a flexible solid-state carbon dot/polyvinyl alcohol (CD/PVA) electrolyte that is ideal for wearable technologies. The lower-right panel shows the ZAB with the ternary Fe-Co-Ni electrocatalyst charging a cell phone. Credit: Nano Research Energy, Tsinghua University Press The effective conversion from fossil fuel-based to renewable energy sources requires cost-efficient, high-capacity, rechargeable batteries. Zinc-air batteries (ZAB) can theoretically store large amounts of energy, but current technologies require th...
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Biologists find nanoplastics in developing chicken heart

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