New approach uses 'cloaked' proteins to deliver cancer-killing therapeutics into cells

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Schematic of the bioreversible anionic cloaking strategy. Chemical modification of surface-exposed lysines with sulfonated cloaking reagents enables complexation and subsequent delivery of protein cargos with cationic lipids. Following endocytic escape, the reagents are cleaved off via the presence of a self-immolative, redox-sensitive disulfide bond to tracelessly deliver the cargo protein in the cytoplasm of a cell. Credit: ACS Central Science (2024). DOI: 10.1021/acscentsci.4c00071 An interdisciplinary collaboration has designed a way to «cloak» proteins so that they can be captured by lipid nanoparticles, which are akin to tiny bubbles of fat. These bubbles are small enough to sneak their hidden cargo into living cells, where the proteins uncloak and exert their therapeutic effect. The generalizable technique could lead to repurposing thousands of commercial protein products, including antibodies, for biological research an...
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Get a full intro course to ChatGPT for just $17

TL;DR: Through June 17, you can score an Introduction to ChatGPT course on sale for just $16.97 (reg. $80).

Artificial intelligence often gets a bad rap, portrayed as either a job-stealing villain or, worse, the future overlord of humanity. But let’s get real, the odds of you reporting to a robot boss anytime soon are pretty slim. And harnessing AI’s potential is the ultimate productivity hack if you know how to use it right.

You can start by learning how to take full advantage of everyone’s new favorite tool, ChatGPT. The Introduction to ChatGPT course is on sale for just $16.97 (reg. $80) through June 17, and it’s designed to help you learn how to augment your skills with this multifunctional AI tool.

Put together by International Open Academy, a leading online learning provider and a one-stop shop for professional development and personal development, this beginner-friendly course walks you through how to make ChatGPT your new best friend at work. It focuses on seven distinct skills, particularly content creation, client services, market research, lead generation, data analytics, sales and marketing, and HR management.

Whether you’re a content marketer perfecting a strategy or a business owner hunting for more sales, this course has got you covered. You can expect to hone your writing skills, learn innovative lead generation methods, get savvy with data analysis, discover new marketing tactics, streamline your business operations, and much more.

The cherry on top? Completing this course earns you Continuing Education (CE) and Continuing Professional Development (CPD) credits to boost your career. But to get a certificate of completion — which is not an accredited degree of any kind — you must first finish each lesson and pass exams with at least a 55% grade.

Mashable Deals

Transform your workflow with the help of artificial intelligence. This introductory ChatGPT course normally retails for $80, but through June 17, you can get it on sale for only $16.97.

StackSocial prices subject to change.

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New approach uses 'cloaked' proteins to deliver cancer-killing therapeutics into cells

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Schematic of the bioreversible anionic cloaking strategy. Chemical modification of surface-exposed lysines with sulfonated cloaking reagents enables complexation and subsequent delivery of protein cargos with cationic lipids. Following endocytic escape, the reagents are cleaved off via the presence of a self-immolative, redox-sensitive disulfide bond to tracelessly deliver the cargo protein in the cytoplasm of a cell. Credit: ACS Central Science (2024). DOI: 10.1021/acscentsci.4c00071 An interdisciplinary collaboration has designed a way to «cloak» proteins so that they can be captured by lipid nanoparticles, which are akin to tiny bubbles of fat. These bubbles are small enough to sneak their hidden cargo into living cells, where the proteins uncloak and exert their therapeutic effect. The generalizable technique could lead to repurposing thousands of commercial protein products, including antibodies, for biological research an...
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