New approach uses 'cloaked' proteins to deliver cancer-killing therapeutics into cells

Image
Schematic of the bioreversible anionic cloaking strategy. Chemical modification of surface-exposed lysines with sulfonated cloaking reagents enables complexation and subsequent delivery of protein cargos with cationic lipids. Following endocytic escape, the reagents are cleaved off via the presence of a self-immolative, redox-sensitive disulfide bond to tracelessly deliver the cargo protein in the cytoplasm of a cell. Credit: ACS Central Science (2024). DOI: 10.1021/acscentsci.4c00071 An interdisciplinary collaboration has designed a way to «cloak» proteins so that they can be captured by lipid nanoparticles, which are akin to tiny bubbles of fat. These bubbles are small enough to sneak their hidden cargo into living cells, where the proteins uncloak and exert their therapeutic effect. The generalizable technique could lead to repurposing thousands of commercial protein products, including antibodies, for biological research an...
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Best app deal: Learn a new language for under £24

TL;DR: As of June 15, get a lifetime subscription to the Beelinguapp language learning app for just £23.62 (reg. £78.81).

When you think about travel planning, you probably picture booking your hotel and packing your bags. But what about preparing to interact with locals who might speak a different native language than you? You don’t have to become fluent — even some basic terms and phrases could be useful. Beelinguapp makes language learning fun with interactive reading and audiobooks, and you can get it on sale today.

Get a lifetime subscription to the Beelinguapp language learning app for just £23.62 (reg. £78.81).

Immersive language learning

Other language learning apps introduce you to basic terms and slowly work up to more advanced vocabulary. Beelinguapp takes a hands-on approach, letting you dive into reading real texts in your new language right away. How? You’ll see side-by-side pages in both your native language and the one you’re trying to learn.

See it in action here:

You could read novels, short stories, science papers, or even fairy tales with Beelinguapp. Along with reading, you can play each sentence aloud and hear it read by a real native language speaker. This gets you familiar with new terms, sentence structure, and pronunciation, all in an engaging way.

Speak, travel, repeat

Beelinguapp has 14 languages to choose from: Spanish, English, German, Portuguese, Korean, French, Hindi, Russian, Turkish, Chinese, Arabic, Italian, Swedish, and Japanese. Focus your efforts on one language, or pick up general vocabulary in a few.

Since you’ll have a lifetime subscription, you can always come back to Beelinguapp to get a refresher on your French before taking a trip to Europe, or start learning a new language before you travel to your next international destination.

Mashable Deals

Speak like a local with a lifetime subscription to Beelinguapp language learning app, now only £23.62 (reg. £78.81), no coupon needed.

Prices subject to change.

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New approach uses 'cloaked' proteins to deliver cancer-killing therapeutics into cells

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Schematic of the bioreversible anionic cloaking strategy. Chemical modification of surface-exposed lysines with sulfonated cloaking reagents enables complexation and subsequent delivery of protein cargos with cationic lipids. Following endocytic escape, the reagents are cleaved off via the presence of a self-immolative, redox-sensitive disulfide bond to tracelessly deliver the cargo protein in the cytoplasm of a cell. Credit: ACS Central Science (2024). DOI: 10.1021/acscentsci.4c00071 An interdisciplinary collaboration has designed a way to «cloak» proteins so that they can be captured by lipid nanoparticles, which are akin to tiny bubbles of fat. These bubbles are small enough to sneak their hidden cargo into living cells, where the proteins uncloak and exert their therapeutic effect. The generalizable technique could lead to repurposing thousands of commercial protein products, including antibodies, for biological research an...
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